Stiff Person Syndrome is a rare autoimmune disorder associated with antibodies against glutamic acid decarboxylase, the key enzyme in γ -aminobutyric acid synthesis. In order to investigate the role of cerebral benzodiazepinereceptor binding in SPS, we performed [ 11 C]flumazenil positron emission tomography in a female patient with SPS compared to nine healthy controls. FMZ is a radioligand to the postsynaptic central benzodiazepine receptor which is co-localized with the GABA-A receptor. In the SPS patient, we found a global reduction of (...) cortical FMZ binding. In addition, distinct local clusters of reduced radiotracer binding were observed. These data provide first in vivo evidence for a reduced postsynaptic GABA-A receptor availability which may reflect the loss of GABAergic neuronal inhibition in SPS. (shrink)

Context: Technology has not only changed the way we teach mathematical concepts but also the nature of knowledge, and thus what is possible to learn. While geometric transformations are recognized to be foundational to the formation of students’ geometric conceptions, little research has focused on how these notions can be introduced in elementary schooling. Problem: This project addressed the need for development of students’ reasoning about and with geometric transformations in elementary school. We investigated the nature of students’ understandings of (...) translations, rotations, scaling, and stretching in two dimensions in the context of use of the software application Graphs ’n Glyphs. More specifically, we explored the question “What is the nature of elementary students’ reasoning of geometric transformations when instruction exploits the technological tool Graphs ’n Glyphs?” Method: Using a design research perspective, we present the conduct of a teaching experiment with one pair of fourth-graders, studying translation and rotation. The project investigated how and to what extent activity using Graphs ’n Glyphs can elicit students’ reasoning about geometric transformations, and explored the constraints and affordances of Graphs ’n Glyphs for thinking-in-change about geometric transformations. Results: The students proved adept using the software with carefully designed tasks to explore the behavior of two-dimensional shapes, distinguish among transformations, and develop predictions. In relation to varied conditions of transformations, they formed generalizations about the way a shape behaves, including the use of referent points in predicting outcomes of translations, and recognizing the role of the center of rotation. Implications: The generalizations that the students developed are foundational for developing an understanding of the properties of transformations in the later years of schooling. Dynamic technological approaches to geometry may prove as valuable to elementary students’ understanding of geometry as it is for older students. Constructivist content: This study contributes to ongoing constructivism/constructionism conversations by concentrating on the transformation of ideas when engaging learners in activity through particular contexts and tools. Key Words: Geometry, transformations, constructionist technologies. (shrink)

Multilingual dictionary of philosophical terms.

Study on the philosophy of semantics in Tantric texts and Sanskrit grammar.

Philosophy; philosophical theology; philosophical anthropology; history.

Este libro presenta más de medio siglo de la historia de España a través de los ojos de un espectador lúcido y atento que nunca ha sido extraño a su propia época. Es un testimonio vital de un gran historiador de la filosofía y un documento valioso para entender algunos aspectos de la historia del pensamiento español y de la evolución de la enseñanza en la segunda mitad del siglo XX. Índice: Prólogo, por Horacio Capel.- Preámbulo.- Infancia y orígenes.- Guerra (...) y posguerra, universidad y milicia.- Segunda juventud y madurez.- En la monarquía de Juan Carlos.- Penúltimas reflexiones (aunque no nuevas).- Epílogo, por Laureano Bonet. (shrink)

The general question to which Edwards here addresses himself is "whether any event whatsoever, and volition in particular, can come to pass without a cause of its existence," and among other arguments for a negative answer he has a reductio ad absurdum, arguing that if an act of will can occur without a cause, then anything at all, no matter how fantastic, can occur without a cause. There is, he says in effect, an inner contradiction in the notion that uncaused (...) events are bound always to be acts of will. We must note, however, in following his argument through, that his language is not quite that which I have just used, and in particular he does not speak primarily of what "occurs" but rather of what "begins to be." He says. (shrink)

Сборник содержит материалы докладов участников межвузовской конференции, посвященной проблемам связи философии, культуры и истории, влиянию социально-культурологических аспектов на развитие философских идей.